Nucleolar caspase-2: Protecting us from DNA damage
نویسندگان
چکیده
Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus.
منابع مشابه
Jcb_201704114 1521..1524
1521 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 6 1521–1523 https://doi.org/10.1083/jcb.201704114 Caspase-2 is a critical component of the cellular machinery designed to remove damaged cells, preventing disease. Consistent with a function in the apoptosis pathway, caspase-2, like caspase-3, is a tumor suppressor (Puccini et al., 2013). Although caspase-2 is required to i...
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